Roadblocks to success for RNA CARs in solid tumors
نویسندگان
چکیده
While CAR therapy has begun to demonstrate efficacy, cell-engineering techniques that result in permanent genomic modification carry several safety concerns. CAR expression driven by RNA creates a platform for delivery of highly-active cell therapy while avoiding long-term CAR-driven toxicity. Using models of pediatric neuroblastoma, we have found that RNA CAR T cell activity is limited by ineffective tumor infiltration.
منابع مشابه
بررسی سونوگرافیک تومورهای سولید کلیه
ABSTRACT: Solid tumors of adult kidney are the most malignant tumors of human body After bladder tumors, they are the commonest solid tumors of urinary tract. There is a tendency to study these lesions by modalities other than sonography and for this reason there are some doubts in studying these tumors by sonography. For resolving these doubts , the first step is to reveal the different son...
متن کاملChimeric Antigen Receptors T Cell Therapy in Solid Tumor: Challenges and Clinical Applications
Adoptive cellular immunotherapy (ACT) employing engineered T lymphocytes expressing chimeric antigen receptors (CARs) has demonstrated promising antitumor effects in advanced hematologic cancers, such as relapsed or refractory acute lymphoblastic leukemia, chronic lymphocytic leukemia, and non-Hodgkin lymphoma, supporting the translation of ACT to non-hematological malignancies. Although CAR T ...
متن کاملBispecific antibody does not induce T-cell death mediated by chimeric antigen receptor against disialoganglioside GD2
Chimeric antigen receptors (CAR) and bispecific antibodies (BsAb) are two powerful immunotherapy approaches for retargeting lymphocytes toward cancer cells. Despite their success in lymphoblastic leukemia, solid tumors have been more recalcitrant. Identifying therapeutic barriers facing CAR-modified (CART) or BsAb-redirected T (BsAb-T) cells should facilitate their clinical translation to solid...
متن کاملMesothelin-Targeted CARs: Driving T Cells to Solid Tumors.
UNLABELLED Chimeric antigen receptors (CAR) are synthetic receptors that target T cells to cell-surface antigens and augment T-cell function and persistence. Mesothelin is a cell-surface antigen implicated in tumor invasion, which is highly expressed in mesothelioma and lung, pancreas, breast, ovarian, and other cancers. Its low-level expression in mesothelia, however, commands thoughtful thera...
متن کاملTargeting the tumor vasculature with TEM8-specific T cells
Background T cell immunotherapy with genetically modified T cells expressing chimeric antigen receptors (CARs) has shown promise in preclinical models as well as early clinical studies. However, patients with solid tumors often do not respond as well as patients with hematological malignancies. This lack of efficacy for solid tumors is most likely due to several factors including a) emergence o...
متن کامل